Covaxin effectively neutralises Delta+ variant: ICMR-NIV study | Hyderabad News – Times of India

HYDERABAD: Covid-19 vaccine Covaxin is effective in neutralising the Delta Plus (AY.1) variant, a study conducted by the Indian Council of Medical Research (ICMR) and the National Institute of Virology, Pune, has found. The Delta Plus variant was first detected in India earlier this year and subsequently in 20 other countries.
The study found that though there was a reduction in NAb titer (concentration of neutralising antibody) in the sera of the three groups that were studied, the concentration of antibodies was enough to effectively neutralise the Delta, Delta Plus and B.1.617.3 variants as compared to the B.1 variant.
The study evaluated the IgG antibody titer (Immunoglobulin G concentration) and neutralizing potential of sera of Covid-19 naive individuals fully vaccinated with Covaxin, Covid-19 recovered cases with two doses of Covaxin and breakthrough cases post-immunization with Covaxin against the Delta, Delta Plus and B.1.617.3 as compared to the B.1 variant.
The research paper titled `Comparable neutralisation of SARS-CoV-2 Delta AY.1 and Delta in individuals sera vaccinated with BBV152’ has been uploaded on bioRxiv, which carries preprints of research papers before they are peer-reviewed. Covaxin’s final Phase III efficacy data had shown the vaccine is 65.2% effective against Delta variant.
For the study, researchers drew sera from 86 individuals, including 42 persons who had never been infected with Covid but were immunised with two doses of Covaxin, 14 people who had recovered from Covid and were vaccinated with two doses of Covaxin and 30 persons who got infected after being immunised with two doses of Covaxin.
“A minor reduction was observed in the neutralizing antibody titer in Covid-19 recovered cases full BBV152 vaccinated and post immunised infected cases compared to Covid-19 naive vaccinated individuals. However, with the observed high titers, the sera of individuals belonging to all the aforementioned groups they would still neutralize the Delta, Delta AY.1 and B.1.617.3 variants effectively,” the researchers said.
“A reduction in neutralizing activity was observed with the Covid-19 naive individuals full vaccinated (1.3, 1.5, 1.9-fold), Covid-19 recovered cases with full BBV152 immunization (2.5, 3.5, 3.8-fold) and breakthrough cases post-immunization (1.9, 2.8, 3.5-fold) against Delta, Delta AY.1 and B.1.617.3, respectively, as compared to B.1 variant,” the paper added.


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